Children’s Hospital Doctor Discusses SCID/Bubble Boy Disease

Children’s Hospital Doctor Discusses SCID/Bubble Boy Disease

Katie DeLong

John Routes from Children’s Hospital of Wisconsin appeared on Live at 12:30 to discuss Severe Combined Immune Deficiency (SCID), which is sometimes known as Bubble Boy Disease.SCID is a genetic disorder that is fatal without early diagnosis and treatment.SCID is the most lethal version of all primary immunodeficiency diseases. It often is called “Boy in the Bubble” after the movie of the same name that starred John Travolta, the true story of a boy with SCID who died at age 12 after spending his life in a plastic bubble because he was so vulnerable to infection.

SCID causes a defect in the white blood cells that helps protect the body from viruses, bacteria and fungi.

Doctors know that SCID is the result of a mutation in one of at least 12 genes, and bone marrow transplants are presently the best treatment.

Warning Signs:
• Eight or more new ear infections within 1 year.
• Recurrent, deep skin or organ abscesses.
• Two or more serious sinus infections within 1 year.
• Persistent thrush in mouth or elsewhere on skin, after 1.
• Two or more months on antibiotics with little effect.
• Need for intravenous antibiotics to clear infections.
• Two or more pneumonias within one year.
• Two or more deep-seated infections.
• Failure of an infant to gain weight or grow normally.
• A family history of Primary Immunodeficiency.

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